CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family ATP-dependent DNA helicase

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P03018
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P03018
UVRD_ECOLI
Escherichia coli K-12
DNA helicase II

PDB Structure

PDB 2IS4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
UvrD helicase unwinds DNA one base pair at a time by a two-part power stroke.
Lee, J.Y., Yang, W.
Cell(Cambridge,Mass.)