CATH Classification

Domain Context

CATH Clusters

Superfamily ATP-grasp fold, B domain
Functional Family D-alanine--D-alanine ligase

Enzyme Information

6.3.2.4
D-alanine--D-alanine ligase.
based on mapping to UniProt Q5HEB7
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.
-!- Involved with EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8, EC 6.3.2.9 and EC 6.3.2.10 in the synthesis of a cell-wall peptide.

UniProtKB Entries (1)

Q5HEB7
DDL_STAAC
Staphylococcus aureus subsp. aureus COL
D-alanine--D-alanine ligase

PDB Structure

PDB 2I87
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies.
Liu, S., Chang, J.S., Herberg, J.T., Horng, M.M., Tomich, P.K., Lin, A.H., Marotti, K.R.
Proc.Natl.Acad.Sci.Usa