CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family TEK receptor tyrosine kinase

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q02763
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

O15123
ANGP2_HUMAN
Homo sapiens
Angiopoietin-2

PDB Structure

PDB 2GY7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex.
Barton, W.A., Tzvetkova-Robev, D., Miranda, E.P., Kolev, M.V., Rajashankar, K.R., Himanen, J.P., Nikolov, D.B.
Nat.Struct.Mol.Biol.