CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2300
Functional Family Arsenate reductase

Enzyme Information

1.20.4.4
Arsenate reductase (thioredoxin).
based on mapping to UniProt P0A006
Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H(2)O.
-!- The enzyme, characterized in bacteria of the Firmicutes phylum, is specific for thioredoxin. -!- It has no activity with glutaredoxin (cf. EC 1.20.4.1). -!- Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7; in other organisms, arsenite can be methylated by EC 2.1.1.137 in a pathway that produces non-toxic organoarsenical compounds. -!- The enzyme also has the activity of EC 3.1.3.48.

UniProtKB Entries (1)

P0A006
ARSC_STAAU
Staphylococcus aureus
Arsenate reductase

PDB Structure

PDB 2FXI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Interplay Between Ion Binding and Catalysis in the Thioredoxin-coupled Arsenate Reductase Family.
Roos, G., Buts, L., Van Belle, K., Brosens, E., Geerlings, P., Loris, R., Wyns, L., Messens, J.
J.Mol.Biol.