CATH Classification

Domain Context

CATH Clusters

Superfamily 3.20.20.220
Functional Family Methylenetetrahydrofolate reductase

Enzyme Information

1.5.1.20
Methylenetetrahydrofolate reductase (NAD(P)H).
based on mapping to UniProt P0AEZ1
5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H.
-!- Menadione can also serve as an electron acceptor. -!- Formerly EC 1.1.1.68, EC 1.1.1.171, EC 1.1.99.15 and EC 1.7.99.5.

UniProtKB Entries (1)

P0AEZ1
METF_ECOLI
Escherichia coli K-12
5,10-methylenetetrahydrofolate reductase

PDB Structure

PDB 2FMO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural Perturbations in the Ala -> Val Polymorphism of Methylenetetrahydrofolate Reductase: How Binding of Folates May Protect against Inactivation
Pejchal, R., Campbell, E., Guenther, B.D., Lennon, B.W., Matthews, R.G., Ludwig, M.L.
Biochemistry