CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family |
Enzyme Information
| 4.1.99.22 |
GTP 3',8-cyclase.
based on mapping to UniProt P69848
GTP + S-adenosyl-L-methionine + reduced electron acceptor = (8S)-3',8- cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor.
-!- The enzyme catalyzes an early step in the biosynthesis of the molybdenum cofactor (MoCo). -!- The enzyme belongs to the superfamily of radical S-adenosyl-L- methionine (radical SAM) enzymes. -!- Formerly EC 4.1.99.18.
|
UniProtKB Entries (1)
| P69848 |
MOAA_STAA8
Staphylococcus aureus subsp. aureus NCTC 8325
GTP 3',8-cyclase
|
PDB Structure
| PDB | 2FB2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism
Proc.Natl.Acad.Sci.USA
|