CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

1.3.98.1
Dihydroorotate oxidase (fumarate).
based on mapping to UniProt Q4D3W2
(S)-dihydroorotate + fumarate = orotate + succinate.
-!- The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. -!- Molecular oxygen can replace fumarate in vitro. -!- Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. -!- Formerly EC 1.3.3.1.

UniProtKB Entries (1)

Q4D3W2
PYRD_TRYCC
Trypanosoma cruzi strain CL Brener
Dihydroorotate dehydrogenase (fumarate)

PDB Structure

PDB 2E68
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate
Inaoka, D.K., Shimizu, H., Sakamoto, K., Shiba, T., Kurisu, G., Nara, T., Aoki, T., Harada, S., Kita, K.
To be Published