CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Probable ATP-dependent RNA helicase DDX4

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt P09052
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

P09052
VASA1_DROME
Drosophila melanogaster
ATP-dependent RNA helicase vasa

PDB Structure

PDB 2DB3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa.
Sengoku, T., Nureki, O., Nakamura, A., Kobayashi, S., Yokoyama, S.
Cell(Cambridge,Mass.)