CATH Classification

Domain Context

CATH Clusters

Superfamily Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family Serine/threonine-protein kinase

Enzyme Information

2.7.11.13
Protein kinase C.
based on mapping to UniProt O94806
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

O94806
KPCD3_HUMAN
Homo sapiens
Serine/threonine-protein kinase D3

PDB Structure

PDB 2D9Z
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of the PH domain of Protein kinase C, nu type from human
Li, H., Tomizawa, T., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S.
To be Published