CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | Hydroxymethylglutaryl-CoA lyase, mitochondrial |
Enzyme Information
| 4.1.3.4 |
Hydroxymethylglutaryl-CoA lyase.
based on mapping to UniProt P35914
(S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate.
|
UniProtKB Entries (1)
| P35914 |
HMGCL_HUMAN
Homo sapiens
Hydroxymethylglutaryl-CoA lyase, mitochondrial
|
PDB Structure
| PDB | 2CW6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria
J.Biol.Chem.
|