CATH Classification

Domain Context

CATH Clusters

Superfamily Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family Serine/threonine-protein kinase

Enzyme Information

2.7.11.13
Protein kinase C.
based on mapping to UniProt Q9BZL6
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q9BZL6
KPCD2_HUMAN
Homo sapiens
Serine/threonine-protein kinase D2

PDB Structure

PDB 2COA
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of the PH domain of protein kinase C, D2 type from human
Li, H., Saito, K., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S.
To be Published