CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.50.40
Functional Family Chromodomain-helicase-DNA-binding protein 2 isoform 1

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt O14646
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P68431
H31_HUMAN
Homo sapiens
Histone H3.1

PDB Structure

PDB 2B2T
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Double chromodomains cooperate to recognize the methylated histone H3 tail.
Flanagan, J.F., Mi, L.Z., Chruszcz, M., Cymborowski, M., Clines, K.L., Kim, Y., Minor, W., Rastinejad, F., Khorasanizadeh, S.
Nature