CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Endochitinase B1

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt Q873X9
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

Q873X9
CHIB1_ASPFM
Aspergillus fumigatus
Endochitinase B1

PDB Structure

PDB 2A3C
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.
Rao, F.V., Andersen, O.A., Vora, K.A., Demartino, J.A., van Aalten, D.M.
Chem.Biol.