CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrodipicolinate Reductase; domain 2
Functional Family 4-hydroxy-tetrahydrodipicolinate reductase

Enzyme Information

1.17.1.8
4-hydroxy-tetrahydrodipicolinate reductase.
based on mapping to UniProt P9WP23
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)(+) + H(2)O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.
-!- Studies of the enzyme from the bacterium Escherichia coli have shown that the enzyme accepts (2S,4S)-4-hydroxy-2,3,4,5- tetrahydrodipicolinate and not (S)-2,3-dihydrodipicolinate as originally thought. -!- Formerly EC 1.3.1.26.

UniProtKB Entries (1)

P9WP23
DAPB_MYCTU
Mycobacterium tuberculosis H37Rv
4-hydroxy-tetrahydrodipicolinate reductase

PDB Structure

PDB 1YL5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of dihydrodipicolinate reductase (DapB) from Mycobacterium tuberculosis in three crystal forms.
Janowski, R., Kefala, G., Weiss, M.S.
Acta Crystallogr.,Sect.D