CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Katanin p60 atpase-containing subunit

Enzyme Information

3.6.4.6
Vesicle-fusing ATPase.
based on mapping to UniProt O75351
ATP + H(2)O = ADP + phosphate.
-!- A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. -!- They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. -!- They include peroxin, which apparently is involved in Zellweger's syndrome.

UniProtKB Entries (1)

O75351
VPS4B_HUMAN
Homo sapiens
Vacuolar protein sorting-associated protein 4B

PDB Structure

PDB 1XWI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and mechanistic studies of VPS4 proteins
Scott, A., Chung, H.Y., Gonciarz-Swiatek, M., Hill, G.C., Whitby, F.G., Gaspar, J., Holton, J.M., Viswanathan, R., Ghaffarian, S., Hill, C.P., Sundquist, W.I.
Embo J.