CATH Classification

Domain Context

CATH Clusters

Superfamily Divalent-metal-dependent TIM barrel enzymes
Functional Family

Enzyme Information

5.3.1.5
Xylose isomerase.
based on mapping to UniProt P12070
D-xylopyranose = D-xylulose.
-!- The enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificity. -!- The enzyme binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyzes ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites. -!- Isomerization proceeds via a hydride-shift mechanism.

UniProtKB Entries (1)

P12070
XYLA_ARTS7
Arthrobacter sp. NRRL B3728
Xylose isomerase

PDB Structure

PDB 1XLJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening followed by a 1,2-hydride shift.
Collyer, C.A., Henrick, K., Blow, D.M.
J.Mol.Biol.