CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family RecBCD enzyme subunit RecB

Enzyme Information

3.1.11.5
Exodeoxyribonuclease V.
based on mapping to UniProt P08394
Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.
-!- Preference for double-stranded DNA. -!- Possesses DNA-dependent ATPase activity. -!- Acts endonucleolytically on single-stranded circular DNA. -!- Similar enzyme: Haemophilus influenzae ATP-dependent DNase.

UniProtKB Entries (1)

P07648
RECC_ECOLI
Escherichia coli K-12
RecBCD enzyme subunit RecC

PDB Structure

PDB 1W36
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Recbcd Enzyme Reveals a Machine for Processing DNA Breaks
Singleton, M.R., Dillingham, M.S., Gaudier, M., Kowalczykowski, S.C., Wigley, D.B.
Nature