CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

2.7.1.21
Thymidine kinase.
based on mapping to UniProt P03176
ATP + thymidine = ADP + thymidine 5'-phosphate.
-!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118 and EC 2.7.4.9. -!- Formerly EC 2.7.1.75.

UniProtKB Entries (1)

P03176
KITH_HHV11
Human alphaherpesvirus 1 strain 17
Thymidine kinase

PDB Structure

PDB 1VTK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue.
Wild, K., Bohner, T., Folkers, G., Schulz, G.E.
Protein Sci.