CATH Domain 1vhcA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family

Enzyme Information

4.1.2.14	2-dehydro-3-deoxy-phosphogluconate aldolase. based on mapping to UniProt P44480 2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate. -!- The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. EC 4.1.2.55). -!- Also acts on 2-oxobutanoate.
4.1.3.16	4-hydroxy-2-oxoglutarate aldolase. based on mapping to UniProt P44480 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. -!- The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. -!- Formerly EC 4.1.2.1 and EC 4.1.2.31.

UniProtKB Entries (1)

ALKH_HAEIN

Haemophilus influenzae Rd KW20

Putative KHG/KDPG aldolase

PDB Structure

PDB	1VHC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural analysis of a set of proteins resulting from a bacterial genomics project Badger, J., Sauder, J.M., Adams, J.M., Antonysamy, S., Bain, K., Bergseid, M.G., Buchanan, S.G., Buchanan, M.D., Batiyenko, Y., Christopher, J.A., Emtage, S., Eroshkina, A., Feil, I., Furlong, E.B., Gajiwala, K.S., Gao, X., He, D., Hendle, J., Huber, A., Hoda, K., Kearins, P., Kissinger, C., Laubert, B., Lewis, H.A., Lin, J., Loomis, K., Lorimer, D., Louie, G., Maletic, M., Marsh, C.D., Miller, I., Molinari, J., Muller-Dieckmann, H.J., Newman, J.M., Noland, B.W., Pagarigan, B., Park, F., Peat, T.S., Post, K.W., Radojicic, S., Ramos, A., Romero, R., Rutter, M.E., Sanderson, W.E., Schwinn, K.D., Tresser, J., Winhoven, J., Wright, T.A., Wu, L., Xu, J., Harris, T.J. Proteins