CATH Classification

Domain Context

CATH Clusters

Superfamily Monomethylamine methyltransferase MtmB
Functional Family Monomethylamine methyltransferase MtmB1

Enzyme Information

2.1.1.248
[Methylamine--corrinoid protein] Co-methyltransferase.
based on mapping to UniProt O30642
Methylamine + a [Co(I) methylamine-specific corrinoid protein] = a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia.
-!- The enzyme, which catalyzes the transfer of a methyl group from methylamine to a methylamine-specific corrinoid protein (MtmC), is involved in methanogenesis from methylamine. -!- The enzyme contains the unusual amino acid pyrrolysine. -!- Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. -!- During methylation the cobalt is oxidized to the Co(III) state. -!- The methylated corrinoid protein is substrate for EC 2.1.1.247.

UniProtKB Entries (1)

O30642
MTMB1_METBA
Methanosarcina barkeri
Monomethylamine methyltransferase MtmB1

PDB Structure

PDB 1TV2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Reactivity and chemical synthesis of L-pyrrolysine- the 22(nd) genetically encoded amino acid
Hao, B., Zhao, G., Kang, P.T., Soares, J.A., Ferguson, T.K., Gallucci, J., Krzycki, J.A., Chan, M.K.
Chem.Biol.