CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrodipicolinate Reductase; domain 2
Functional Family

Enzyme Information

5.5.1.4
Inositol-3-phosphate synthase.
based on mapping to UniProt P11986
D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate.
-!- The NAD(+) dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1; finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form.

UniProtKB Entries (1)

P11986
INO1_YEAST
Saccharomyces cerevisiae S288C
Inositol-3-phosphate synthase

PDB Structure

PDB 1RM0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of the 1L-myo-inositol-1-phosphate synthase-NAD+-2-deoxy-D-glucitol 6-(E)-vinylhomophosphonate complex demands a revision of the enzyme mechanism.
Jin, X., Foley, K.M., Geiger, J.H.
J.Biol.Chem.