CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Chitinase A

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt P07254
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

P07254
CHIA_SERMA
Serratia marcescens
Chitinase A

PDB Structure

PDB 1RD6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Mutation of a conserved tryptophan in the chitin-binding cleft of Serratia marcescens chitinase A enhances transglycosylation.
Aronson, N.N., Halloran, B.A., Alexeyev, M.F., Zhou, X.E., Wang, Y., Meehan, E.J., Chen, L.
Biosci.Biotechnol.Biochem.