CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Nicotinate-nucleotide pyrophosphorylase, carboxylating

Enzyme Information

2.4.2.19
Nicotinate-nucleotide diphosphorylase (carboxylating).
based on mapping to UniProt P9WJJ7
Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3- dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- The reaction is catalyzed in the opposite direction. -!- Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD(+) biosynthesis enzyme shared by both eukaryotes and prokaryotes.

UniProtKB Entries (1)

P9WJJ7
NADC_MYCTU
Mycobacterium tuberculosis H37Rv
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

PDB Structure

PDB 1QPQ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target.
Sharma, V., Grubmeyer, C., Sacchettini, J.C.
Structure