CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family ATP-dependent DNA helicase

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P56255
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P56255
PCRA_GEOSE
Geobacillus stearothermophilus
ATP-dependent DNA helicase PcrA

PDB Structure

PDB 1QHG
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
DNA binding mediates conformational changes and metal ion coordination in the active site of PcrA helicase.
Soultanas, P., Dillingham, M.S., Velankar, S.S., Wigley, D.B.
J.Mol.Biol.