CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Estrogen sulfotransferase

Enzyme Information

2.8.2.2
Alcohol sulfotransferase.
based on mapping to UniProt O00204
3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.
-!- Primary and secondary alcohols, including aliphatic alcohols, ascorbate, chloramphenicol, ephedrine and hydroxysteroids, but not phenolic steroids, can act as acceptors (cf. EC 2.8.2.15).

UniProtKB Entries (1)

O00204
ST2B1_HUMAN
Homo sapiens
Sulfotransferase family cytosolic 2B member 1

PDB Structure

PDB 1Q1Z
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms.
Lee, K.A., Fuda, H., Lee, Y.C., Negishi, M., Strott, C.A., Pedersen, L.C.
J.Biol.Chem.