CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.100 | NADP-dependent oxidoreductase domain |
Domain Context
CATH Clusters
| Superfamily | NADP-dependent oxidoreductase domain |
| Functional Family | Aldo-keto reductase family 1 member C3 |
Enzyme Information
| 1.1.1.189 |
Prostaglandin-E(2) 9-reductase.
based on mapping to UniProt P80508
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.
-!- Reduces prostaglandin E(2) to prostaglandin F(2)-alpha. -!- A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds. -!- May be identical with EC 1.1.1.197.
|
| 1.1.1.149 |
20-alpha-hydroxysteroid dehydrogenase.
based on mapping to UniProt P80508
17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) = 17-alpha- hydroxyprogesterone + NAD(P)H.
-!- Re-specific with respect to NAD(P)(+) (cf. EC 1.1.1.62).
|
UniProtKB Entries (1)
| P80508 |
PE2R_RABIT
Oryctolagus cuniculus
Prostaglandin-E(2) 9-reductase
|
PDB Structure
| PDB | 1Q13 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily.
J. Mol. Biol.
|