CATH Classification

Domain Context

CATH Clusters

Superfamily Metal-dependent hydrolases
Functional Family Parathion hydrolase

Enzyme Information

3.1.8.1
Aryldialkylphosphatase.
based on mapping to UniProt P0A433
An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.
-!- Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. -!- Inhibited by chelating agents. -!- Previously regarded as identical with EC 3.1.1.2.

UniProtKB Entries (1)

P0A433
OPD_SPHSA
Sphingobium fuliginis
Parathion hydrolase

PDB Structure

PDB 1P6C
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site.
Hill, C.M., Li, W.S., Thoden, J.B., Holden, H.M., Raushel, F.M.
J.Am.Chem.Soc.