CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoenolpyruvate-binding domains
Functional Family 2-methylisocitrate lyase

Enzyme Information

4.1.3.30
Methylisocitrate lyase.
based on mapping to UniProt P77541
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.
-!- Acts on threo-D(s)-2-methylisocitrate, but not on threo-D(s)- isocitrate, threo-DL-isocitrate or erythro-L(s)-isocitrate.

UniProtKB Entries (1)

P77541
PRPB_ECOLI
Escherichia coli K-12
2-methylisocitrate lyase

PDB Structure

PDB 1OQF
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of 2-methylisocitrate lyase in complex with product and with isocitrate inhibitor provide insight into lyase substrate specificity, catalysis and evolution.
Liu, S., Lu, Z., Han, Y., Melamud, E., Dunaway-Mariano, D., Herzberg, O.
Biochemistry