CATH Classification

Domain Context

CATH Clusters

Superfamily Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family Phosphoinositide phospholipase C

Enzyme Information

3.1.4.11
Phosphoinositide phospholipase C.
based on mapping to UniProt P10688
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.

UniProtKB Entries (1)

P10688
PLCD1_RAT
Rattus norvegicus
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

PDB Structure

PDB 1MAI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain.
Ferguson, K.M., Lemmon, M.A., Schlessinger, J., Sigler, P.B.
Cell(Cambridge,Mass.)