CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Adenylyl-sulfate kinase

Enzyme Information

2.7.1.25
Adenylyl-sulfate kinase.
based on mapping to UniProt Q12657
ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate.
-!- The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate and the second step is catalyzed by the APS kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme bound APS and ATP. -!- This is in contrast to what is found in bacteria, yeasts, fungi and plants, where the formation of PAPS is carried out by two individual polypeptides, EC 2.7.7.4 and EC 2.7.1.25.

UniProtKB Entries (1)

Q12657
KAPS_PENCH
Penicillium chrysogenum
Adenylyl-sulfate kinase

PDB Structure

PDB 1M7G
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Ligand-Induced Structural Changes in Adenosine 5'-Phosphosulfate Kinase from Penicillium chrysogenum.
Lansdon, E.B., Segel, I.H., Fisher, A.J.
Biochemistry