CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Indole-3-glycerol phosphate synthase

Enzyme Information

4.1.1.48
Indole-3-glycerol-phosphate synthase.
based on mapping to UniProt Q06121
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C- (3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.
-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).

UniProtKB Entries (1)

Q06121
TRPC_SACS2
Saccharolobus solfataricus P2
Indole-3-glycerol phosphate synthase

PDB Structure

PDB 1LBL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The catalytic mechanism of indole-3-glycerol phosphate synthase: Crystal structures of complexes of the enzyme from Sulfolobus solfataricus with the substrate analogue, substrate, and product
Hennig, M., Darimont, B.D., Jansonius, J.N., Kirschner, K.
J.Mol.Biol.