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CATH Classification

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family Caffeic acid 3-O-methyltransferase

Enzyme Information

2.1.1.68
Caffeate O-methyltransferase.
based on mapping to UniProt P28002
S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L- homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate.
-!- 3,4-dihydroxybenzaldehyde and catechol can act as acceptor, more slowly.

UniProtKB Entries (1)

P28002
COMT1_MEDSA
Medicago sativa
Caffeic acid 3-O-methyltransferase

PDB Structure

PDB 1KYW
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase.
Zubieta, C., Kota, P., Ferrer, J.L., Dixon, R.A., Noel, J.P.
Plant Cell
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