CATH Classification

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Thymidine kinase

Enzyme Information

2.7.1.21
Thymidine kinase.
based on mapping to UniProt P03176
ATP + thymidine = ADP + thymidine 5'-phosphate.
-!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118, and EC 2.7.4.9. -!- Formerly EC 2.7.1.75.

UniProtKB Entries (1)

P03176
KITH_HHV11
Herpes simplex virus (type 1 / strain 17)
Thymidine kinase

PDB Structure

PDB 1KIM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Champness, J.N., Bennett, M.S., Wien, F., Visse, R., Summers, W.C., Herdewijn, P., de Clerq, E., Ostrowski, T., Jarvest, R.L., Sanderson, M.R.
Proteins