CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Pancreatic alpha-amylase

Enzyme Information

3.2.1.1
Alpha-amylase.
based on mapping to UniProt P04746
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.
-!- Acts on starch, glycogen and related polysaccharides and oligosaccharides in a random manner; reducing groups are liberated in the alpha-configuration. -!- The term 'alpha' relates to the initial anomeric configuration of the free sugar group released and not to the configuration of the linkage hydrolyzed.

UniProtKB Entries (1)

P04746
AMYP_HUMAN
Homo sapiens
Pancreatic alpha-amylase

PDB Structure

PDB 1KBB
External Links
Method X-RAY DIFFRACTION
Organism Pichia
Primary Citation
Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids.
Rydberg, E.H., Li, C., Maurus, R., Overall, C.M., Brayer, G.D., Withers, S.G.
Biochemistry