CATH Classification

Domain Context

CATH Clusters

Superfamily Mur ligase, C-terminal domain
Functional Family

Enzyme Information

6.3.2.10
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase.
based on mapping to UniProt P11880
ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl- D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D- glutamyl-L-lysyl-D-alanyl-D-alanine.
-!- Involved with EC 6.3.2.4, EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8 and EC 6.3.2.9 in the synthesis of a cell-wall peptide. -!- Also catalyzes the reaction when the C-terminal residue of the tripeptide is meso-2,4-diaminoheptanedioate (acylated at its L-center), linking the D-Ala--D-Ala to the carboxy group of the L-center. -!- Formerly EC 6.3.2.15.

UniProtKB Entries (1)

P11880
MURF_ECOLI
Escherichia coli K-12
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

PDB Structure

PDB 1GG4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolution.
Yan, Y., Munshi, S., Leiting, B., Anderson, M.S., Chrzas, J., Chen, Z.
J.Mol.Biol.