CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt P07254
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

P07254
CHIA_SERMA
Serratia marcescens
Chitinase A

PDB Structure

PDB 1FFR
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
High resolution structural analyses of mutant chitinase A complexes with substrates provide new insight into the mechanism of catalysis.
Papanikolau, Y., Prag, G., Tavlas, G., Vorgias, C.E., Oppenheim, A.B., Petratos, K.
Biochemistry