CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoenolpyruvate-binding domains
Functional Family Isocitrate lyase

Enzyme Information

4.1.3.30
Methylisocitrate lyase.
based on mapping to UniProt P9WKK7
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.
-!- Acts on threo-D(s)-2-methylisocitrate, but not on threo-D(s)- isocitrate, threo-DL-isocitrate or erythro-L(s)-isocitrate.
4.1.3.1
Isocitrate lyase.
based on mapping to UniProt P9WKK7
Isocitrate = succinate + glyoxylate.
-!- The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-1,2,3- tricarboxylate.

UniProtKB Entries (1)

P9WKK7
ACEA_MYCTU
Mycobacterium tuberculosis H37Rv
Isocitrate lyase

PDB Structure

PDB 1F8I
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis.
Sharma, V., Sharma, S., Hoener zu Bentrup, K., McKinney, J.D., Russell, D.G., Jacobs Jr., W.R., Sacchettini, J.C.
Nat.Struct.Biol.