CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydropteroate synthase-like
Functional Family 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase

Enzyme Information

2.1.1.258
5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase.
based on mapping to UniProt Q46389
A [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate = a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate.
-!- Catalyzes the transfer of a methyl group from the N(5) group of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein. -!- Involved, together with EC 1.2.7.4 and EC 2.3.1.169, in the reductive acetyl coenzyme A (Wood-Ljungdahl) pathway of autotrophic carbon fixation in various bacteria and archaea.

UniProtKB Entries (1)

Q46389
ACSE_MOOTH
Moorella thermoacetica
5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase

PDB Structure

PDB 1F6Y
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase.
Doukov, T., Seravalli, J., Stezowski, J.J., Ragsdale, S.W.
Structure Fold.Des.