CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Fructose-bisphosphate aldolase

Enzyme Information

4.1.2.13
Fructose-bisphosphate aldolase.
based on mapping to UniProt P07752
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
-!- Also acts on (3S,4R)-ketose 1-phosphates. -!- The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc. -!- Formerly EC 4.1.2.7.

UniProtKB Entries (1)

P07752
ALF_TRYBB
Trypanosoma brucei brucei
Fructose-bisphosphate aldolase, glycosomal

PDB Structure

PDB 1F2J
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of type 2 peroxisomal targeting signals in two trypanosomatid aldolases.
Chudzik, D.M., Michels, P.A., de Walque, S., Hol, W.G.
J.Mol.Biol.