CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydropteroate synthase-like
Functional Family Dihydropteroate synthase

Enzyme Information

2.5.1.15
Dihydropteroate synthase.
based on mapping to UniProt P9WND1
6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.
-!- The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). -!- The enzyme exists in varying types of multifunctional proteins in different organisms. -!- The enzyme from the plant Arabidopsis thaliana also harbors the activity of EC 2.7.6.3, while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with the two above mentioned activities as well as EC 4.1.2.25.

UniProtKB Entries (1)

P9WND1
DHPS1_MYCTU
Mycobacterium tuberculosis H37Rv
Dihydropteroate synthase

PDB Structure

PDB 1EYE
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action.
Baca, A.M., Sirawaraporn, R., Turley, S., Sirawaraporn, W., Hol, W.G.
J.Mol.Biol.