CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family coagulation factor XIII A chain

Enzyme Information

2.3.2.13
Protein-glutamine gamma-glutamyltransferase.
based on mapping to UniProt P00488
A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)- (gamma-glutamyl)-L-lysine cross-link + NH(3).
-!- The gamma-carboxymide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N(6)-(5-glutamyl)lysine cross-links.

UniProtKB Entries (1)

P00488
F13A_HUMAN
Homo sapiens
Coagulation factor XIII A chain

PDB Structure

PDB 1EX0
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Tryptophan 279 is Essential for the Transglutaminase Activity of Coagulation Factor XIII: Functional and Structural Characterization
Garzon, R.J., Pratt, K.P., Bishop, P.D., Le Trong, I., Stenkamp, R.E., Teller, D.C.
To be Published