CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | Dihydroorotate dehydrogenase |
Enzyme Information
| 1.3.1.14 |
Dihydroorotate dehydrogenase (NAD(+)).
based on mapping to UniProt P54322
(S)-dihydroorotate + NAD(+) = orotate + NADH.
-!- The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit. -!- The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. -!- Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
|
UniProtKB Entries (1)
| P56968 |
PYRK_LACLM
Lactococcus lactis subsp. cremoris MG1363
Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit
|
PDB Structure
| PDB | 1EP2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster.
Structure Fold.Des.
|