CATH Classification

Domain Context

CATH Clusters

Superfamily SH3 Domains
Functional Family Tyrosine-protein kinase Fyn

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P06241
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (2)

P03406
NEF_HV1BR
Human immunodeficiency virus type 1 (BRU ISOLATE)
Protein Nef
P06241
FYN_HUMAN
Homo sapiens
Tyrosine-protein kinase Fyn

PDB Structure

PDB 1EFN
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.
Lee, C.H., Saksela, K., Mirza, U.A., Chait, B.T., Kuriyan, J.
Cell(Cambridge,Mass.)