CATH Classification

Domain Context

CATH Clusters

Superfamily Mur ligase, C-terminal domain
Functional Family UDP-N-acetylmuramoylalanine--D-glutamate ligase

Enzyme Information

6.3.2.9
UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase.
based on mapping to UniProt P14900
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate.
-!- Involved in the synthesis of a cell-wall peptide in bacteria.

UniProtKB Entries (1)

P14900
MURD_ECOLI
Escherichia coli K-12
UDP-N-acetylmuramoylalanine--D-glutamate ligase

PDB Structure

PDB 1EEH
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
"Open" structures of MurD: domain movements and structural similarities with folylpolyglutamate synthetase.
Bertrand, J.A., Fanchon, E., Martin, L., Chantalat, L., Auger, G., Blanot, D., van Heijenoort, J., Dideberg, O.
J.Mol.Biol.