CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Class II fructose-bisphosphate aldolase

Enzyme Information

4.1.2.13
Fructose-bisphosphate aldolase.
based on mapping to UniProt P0AB71
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
-!- Also acts on (3S,4R)-ketose 1-phosphates. -!- The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc. -!- Formerly EC 4.1.2.7.

UniProtKB Entries (1)

P0AB71
ALF_ECOLI
Escherichia coli K-12
Fructose-bisphosphate aldolase class 2

PDB Structure

PDB 1B57
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of Escherichia coli class II fructose-1, 6-bisphosphate aldolase in complex with phosphoglycolohydroxamate reveals details of mechanism and specificity.
Hall, D.R., Leonard, G.A., Reed, C.D., Watt, C.I., Berry, A., Hunter, W.N.
J.Mol.Biol.