PDB 5xp3

PDB Information

PDB5XP3
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceSus scrofa
Primary Citation
The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
Jianhong, Y., Wei, Y., Yamei, Y., Yuxi, W., Tao, Y., Linlin, X., Xue, Y., Caofeng, L., Zuowei, L., Xiaoxin, C., Mengshi, H., Li, Z., Qiang, Q., Heying, P., Dan, L., Fang, W., Peng, B., Jiaolin, W., Haoyu, Y., Lijuan, C.
J. Biol. Chem.
HeaderStructural Protein
Released2017-05-31
Resolution2.300
CATH Insert Date14 Nov, 2017

PDB Images (23)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5xp3A01 10 Dec, 2017 3.40.50.1440 Assigned
5xp3A02 10 Dec, 2017 3.30.1330.20 Assigned
5xp3A03 10 Dec, 2017 1.10.287.600 Assigned
5xp3B01 10 Dec, 2017 3.40.50.1440 Assigned
5xp3B02 10 Dec, 2017 3.30.1330.20 Assigned
5xp3B03 10 Dec, 2017 1.10.287.600 Assigned
5xp3C01 10 Dec, 2017 3.40.50.1440 Assigned
5xp3C02 10 Dec, 2017 3.30.1330.20 Assigned
5xp3C03 10 Dec, 2017 1.10.287.600 Assigned
5xp3D01 10 Dec, 2017 3.40.50.1440 Assigned
5xp3D02 10 Dec, 2017 3.30.1330.20 Assigned
5xp3D03 10 Dec, 2017 1.10.287.600 Assigned
5xp3E01 10 Dec, 2017 6.10.280.30 Assigned
5xp3F01 10 Dec, 2017 3.40.50.11480 Assigned
5xp3F02 10 Dec, 2017 3.30.470.20 Assigned
5xp3F03 10 Dec, 2017 3.30.1490.20 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
E1BQ43 E1BQ43_CHICK Gallus gallus Uncharacterized protein
Q2XVP4 TBA1B_PIG Sus scrofa Tubulin alpha-1B chain
P63043 STMN4_RAT Rattus norvegicus Stathmin-4
P02554 TBB_PIG Sus scrofa Tubulin beta chain
Q2XVP4 TBA1B_PIG Sus scrofa Tubulin alpha-1B chain
P02554 TBB_PIG Sus scrofa Tubulin beta chain