PDB 5hxb

PDB Links
Overview

PDB Information

PDB	5HXB
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Matyskiela, M.E., Lu, G., Ito, T., Pagarigan, B., Lu, C.C., Miller, K., Fang, W., Wang, N.Y., Nguyen, D., Houston, J., Carmel, G., Tran, T., Riley, M., Nosaka, L., Lander, G.C., Gaidarova, S., Xu, S., Ruchelman, A.L., Handa, H., Carmichael, J., Daniel, T.O., Cathers, B.E., Lopez-Girona, A., Chamberlain, P.P. Nature
Header	Ligase
Released	2016-01-30
Resolution	3.600
CATH Insert Date	17 Jul, 2016

PDB Images (25)

5hxb

PDB 5hxb

5hxbA

PDB Chain 5hxbA

5hxbB

PDB Chain 5hxbB

5hxbC

PDB Chain 5hxbC

5hxbX

PDB Chain 5hxbX

5hxbY

PDB Chain 5hxbY

5hxbZ

PDB Chain 5hxbZ

5hxbA01

CATH Domain 5hxbA01

5hxbA02

CATH Domain 5hxbA02

5hxbB01

CATH Domain 5hxbB01

5hxbB02

CATH Domain 5hxbB02

5hxbB03

CATH Domain 5hxbB03

5hxbB04

CATH Domain 5hxbB04

5hxbC01

CATH Domain 5hxbC01

5hxbC02

CATH Domain 5hxbC02

5hxbC03

CATH Domain 5hxbC03

5hxbX01

CATH Domain 5hxbX01

5hxbX02

CATH Domain 5hxbX02

5hxbY01

CATH Domain 5hxbY01

5hxbY02

CATH Domain 5hxbY02

5hxbY03

CATH Domain 5hxbY03

5hxbY04

CATH Domain 5hxbY04

5hxbZ01

CATH Domain 5hxbZ01

5hxbZ02

CATH Domain 5hxbZ02

5hxbZ03

CATH Domain 5hxbZ03

PDB Prints

PDB Chains (6)

Chain ID	Date inserted into CATH	CATH Status
A	18 Jul, 2016	Chopped
B	18 Jul, 2016	Chopped
C	18 Jul, 2016	Chopped
X	18 Jul, 2016	Chopped
Y	18 Jul, 2016	Chopped
Z	18 Jul, 2016	Chopped

CATH Domains (18)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5hxbA01	01 Sep, 2016	2.40.30.10	Assigned
5hxbA02	01 Sep, 2016	2.40.30.10	Assigned
5hxbB01	01 Dec, 2017	2.130.10.10	Assigned
5hxbB02	01 Dec, 2017	2.130.10.10	Assigned
5hxbB03	01 Dec, 2017	2.130.10.10	Assigned
5hxbB04	01 Dec, 2017	1.10.150.910	Assigned
5hxbC01	01 Dec, 2017	2.170.150.20	Assigned
5hxbC02	01 Dec, 2017	2.30.130.40	Assigned
5hxbC03	01 Dec, 2017	1.20.58.1480	Assigned
5hxbX01	01 Sep, 2016	2.40.30.10	Assigned
5hxbX02	01 Sep, 2016	2.40.30.10	Assigned
5hxbY01	04 Jan, 2017	2.130.10.10	Assigned
5hxbY02	04 Jan, 2017	2.130.10.10	Assigned
5hxbY03	04 Jan, 2017	2.130.10.10	Assigned
5hxbY04	04 Jan, 2017	1.10.150.910	Assigned
5hxbZ01	01 Dec, 2017	2.170.150.20	Assigned
5hxbZ02	01 Dec, 2017	2.30.130.40	Assigned
5hxbZ03	01 Dec, 2017	1.20.58.1480	Assigned

UniProtKB Entries (6)

Accession	Gene ID	Taxon	Description
P15170	ERF3A_HUMAN	Homo sapiens	Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Q16531	DDB1_HUMAN	Homo sapiens	DNA damage-binding protein 1
P15170	ERF3A_HUMAN	Homo sapiens	Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Q96SW2	CRBN_HUMAN	Homo sapiens	Protein cereblon
Q96SW2	CRBN_HUMAN	Homo sapiens	Protein cereblon
Q16531	DDB1_HUMAN	Homo sapiens	DNA damage-binding protein 1