PDB 5hxb

PDB Information

PDB5HXB
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Matyskiela, M.E., Lu, G., Ito, T., Pagarigan, B., Lu, C.C., Miller, K., Fang, W., Wang, N.Y., Nguyen, D., Houston, J., Carmel, G., Tran, T., Riley, M., Nosaka, L., Lander, G.C., Gaidarova, S., Xu, S., Ruchelman, A.L., Handa, H., Carmichael, J., Daniel, T.O., Cathers, B.E., Lopez-Girona, A., Chamberlain, P.P.
Nature
HeaderLigase
Released2016-01-30
Resolution3.600
CATH Insert Date17 Jul, 2016

PDB Images (25)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 18 Jul, 2016 Chopped
B 18 Jul, 2016 Chopped
C 18 Jul, 2016 Chopped
X 18 Jul, 2016 Chopped
Y 18 Jul, 2016 Chopped
Z 18 Jul, 2016 Chopped

CATH Domains (18)

Domain ID Date inserted into CATH Superfamily CATH Status
5hxbA01 01 Sep, 2016 2.40.30.10 Assigned
5hxbA02 01 Sep, 2016 2.40.30.10 Assigned
5hxbB01 01 Dec, 2017 2.130.10.10 Assigned
5hxbB02 01 Dec, 2017 2.130.10.10 Assigned
5hxbB03 01 Dec, 2017 2.130.10.10 Assigned
5hxbB04 01 Dec, 2017 1.10.150.910 Assigned
5hxbC01 01 Dec, 2017 2.170.150.20 Assigned
5hxbC02 01 Dec, 2017 2.30.130.40 Assigned
5hxbC03 01 Dec, 2017 1.20.58.1480 Assigned
5hxbX01 01 Sep, 2016 2.40.30.10 Assigned
5hxbX02 01 Sep, 2016 2.40.30.10 Assigned
5hxbY01 04 Jan, 2017 2.130.10.10 Assigned
5hxbY02 04 Jan, 2017 2.130.10.10 Assigned
5hxbY03 04 Jan, 2017 2.130.10.10 Assigned
5hxbY04 04 Jan, 2017 1.10.150.910 Assigned
5hxbZ01 01 Dec, 2017 2.170.150.20 Assigned
5hxbZ02 01 Dec, 2017 2.30.130.40 Assigned
5hxbZ03 01 Dec, 2017 1.20.58.1480 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
P15170 ERF3A_HUMAN Homo sapiens Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Q16531 DDB1_HUMAN Homo sapiens DNA damage-binding protein 1
P15170 ERF3A_HUMAN Homo sapiens Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Q96SW2 CRBN_HUMAN Homo sapiens Protein cereblon
Q96SW2 CRBN_HUMAN Homo sapiens Protein cereblon
Q16531 DDB1_HUMAN Homo sapiens DNA damage-binding protein 1