PDB Information

PDB4YFX
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli #1/H766
Gene SourceEscherichia coli O139:H28 (strain E24377A / ETEC)
Primary Citation
X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.
Molodtsov, V., Fleming, P.R., Eyermann, C.J., Ferguson, A.D., Foulk, M.A., McKinney, D.C., Masse, C.E., Buurman, E.T., Murakami, K.S.
J.Med.Chem.
HeaderTranscription/Transcription Inhibitor
Released2015-02-25
Resolution3.840
CATH Insert Date28 Jun, 2015

PDB Images (30)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped
C 29 Jun, 2015 Holding pen
D 29 Jun, 2015 Holding pen
E 29 Jun, 2015 Chopped
F 29 Jun, 2015 Chopped
G 29 Jun, 2015 Chopped
H 29 Jun, 2015 Chopped
I 29 Jun, 2015 Holding pen
J 29 Jun, 2015 Holding pen
K 29 Jun, 2015 Chopped
L 29 Jun, 2015 Chopped

CATH Domains (17)

Domain ID Date inserted into CATH Superfamily CATH Status
4yfxA01 22 Jul, 2015 3.30.1360.10 Assigned
4yfxA02 22 Jul, 2015 2.170.120.12 Assigned
4yfxB01 21 Jul, 2016 3.30.1360.10 Assigned
4yfxB02 21 Jul, 2016 2.170.120.12 Assigned
4yfxB03 21 Jul, 2016 1.10.150.20 Assigned
4yfxE00 22 Jul, 2015 3.90.940.10 Assigned
4yfxF01 22 Jul, 2015 1.10.601.10 Assigned
4yfxF02 22 Jul, 2015 1.10.10.10 Assigned
4yfxF03 22 Jul, 2015 1.10.10.10 Assigned
4yfxG01 21 Jul, 2016 3.30.1360.10 Assigned
4yfxG02 21 Jul, 2016 2.170.120.12 Assigned
4yfxH01 22 Jul, 2016 3.30.1360.10 Assigned
4yfxH02 22 Jul, 2016 2.170.120.12 Assigned
4yfxK00 22 Jul, 2015 3.90.940.10 Assigned
4yfxL01 22 Jul, 2015 1.10.601.10 Assigned
4yfxL02 22 Jul, 2015 1.10.10.10 Assigned
4yfxL03 22 Jul, 2015 1.10.10.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
P00579 RPOD_ECOLI Escherichia coli K-12 RNA polymerase sigma factor RpoD
A7ZUK2 RPOC_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit beta'
A7ZUK2 RPOC_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit beta'
A7ZTK1 RPOZ_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit omega
A7ZUK1 RPOB_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit beta
P00579 RPOD_ECOLI Escherichia coli K-12 RNA polymerase sigma factor RpoD
A7ZSI4 RPOA_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit alpha
A7ZTK1 RPOZ_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit omega
A7ZSI4 RPOA_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit alpha
A7ZUK1 RPOB_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit beta
A7ZSI4 RPOA_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit alpha
A7ZSI4 RPOA_ECO24 Escherichia coli O139:H28 str. E24377A DNA-directed RNA polymerase subunit alpha