PDB Information

PDB4X63
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Chan-Penebre, E., Kuplast, K.G., Majer, C.R., Boriack-Sjodin, P.A., Wigle, T.J., Johnston, L.D., Rioux, N., Munchhof, M.J., Jin, L., Jacques, S.L., West, K.A., Lingaraj, T., Stickland, K., Ribich, S.A., Raimondi, A., Scott, M.P., Waters, N.J., Pollock, R.M., Smith, J.J., Barbash, O., Pappalardi, M., Ho, T.F., Nurse, K., Oza, K.P., Gallagher, K.T., Kruger, R., Moyer, M.P., Copeland, R.A., Chesworth, R., Duncan, K.W.
Nat.Chem.Biol.
HeaderTransferase/Transferase Inhibitor
Released2014-12-06
Resolution3.050
CATH Insert Date28 Jun, 2015

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4x63A01 22 Jul, 2015 3.20.20.150 Assigned
4x63A02 22 Jul, 2015 3.40.50.150 Assigned
4x63A03 22 Jul, 2015 2.70.160.11 Assigned
4x63B00 22 Jul, 2015 2.130.10.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q9BQA1 MEP50_HUMAN Homo sapiens Methylosome protein 50
O14744 ANM5_HUMAN Homo sapiens Protein arginine N-methyltransferase 5