PDB 4u01

PDB Links
Overview

PDB Information

PDB	4U01
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Hepatitis C virus (isolate Con1)
Primary Citation	Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320. Parsy, C.C., Alexandre, F.R., Bidau, V., Bonnaterre, F., Brandt, G., Caillet, C., Cappelle, S., Chaves, D., Convard, T., Derock, M., Gloux, D., Griffon, Y., Lallos, L.B., Leroy, F., Liuzzi, M., Loi, A.G., Moulat, L., Chiara, M., Rahali, H., Roques, V., Rosinovsky, E., Savin, S., Seifer, M., Standring, D., Surleraux, D. Bioorg.Med.Chem.Lett.
Header	Hydrolase
Released	2014-07-11
Resolution	2.800
CATH Insert Date	16 Aug, 2015

PDB Images (37)

4u01

PDB 4u01

4u01A

PDB Chain 4u01A

4u01B

PDB Chain 4u01B

4u01C

PDB Chain 4u01C

4u01D

PDB Chain 4u01D

4u01E

PDB Chain 4u01E

4u01F

PDB Chain 4u01F

4u01G

PDB Chain 4u01G

4u01H

PDB Chain 4u01H

4u01J

PDB Chain 4u01J

4u01K

PDB Chain 4u01K

4u01L

PDB Chain 4u01L

4u01M

PDB Chain 4u01M

4u01N

PDB Chain 4u01N

4u01O

PDB Chain 4u01O

4u01P

PDB Chain 4u01P

4u01Q

PDB Chain 4u01Q

4u01T

PDB Chain 4u01T

4u01U

PDB Chain 4u01U

4u01A01

CATH Domain 4u01A01

4u01A02

CATH Domain 4u01A02

4u01B01

CATH Domain 4u01B01

4u01B02

CATH Domain 4u01B02

4u01C01

CATH Domain 4u01C01

4u01C02

CATH Domain 4u01C02

4u01D01

CATH Domain 4u01D01

4u01D02

CATH Domain 4u01D02

4u01E01

CATH Domain 4u01E01

4u01E02

CATH Domain 4u01E02

4u01F01

CATH Domain 4u01F01

4u01F02

CATH Domain 4u01F02

4u01G01

CATH Domain 4u01G01

4u01G02

CATH Domain 4u01G02

4u01H01

CATH Domain 4u01H01

4u01H02

CATH Domain 4u01H02

4u01J01

CATH Domain 4u01J01

4u01J02

CATH Domain 4u01J02

PDB Prints

PDB Chains (18)

Chain ID	Date inserted into CATH	CATH Status
A	17 Aug, 2015	Chopped
B	17 Aug, 2015	Chopped
C	17 Aug, 2015	Chopped
D	17 Aug, 2015	Chopped
E	17 Aug, 2015	Chopped
F	17 Aug, 2015	Chopped
G	17 Aug, 2015	Chopped
H	17 Aug, 2015	Chopped
J	17 Aug, 2015	Chopped
K	17 Aug, 2015	Rejected
L	17 Aug, 2015	Rejected
M	17 Aug, 2015	Rejected
N	17 Aug, 2015	Rejected
O	17 Aug, 2015	Rejected
P	17 Aug, 2015	Rejected
Q	17 Aug, 2015	Rejected
T	17 Aug, 2015	Rejected
U	17 Aug, 2015	Rejected

CATH Domains (18)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4u01A01	24 Aug, 2015	2.40.10.120	Assigned
4u01A02	24 Aug, 2015	2.40.10.10	Assigned
4u01B01	24 Aug, 2015	2.40.10.120	Assigned
4u01B02	24 Aug, 2015	2.40.10.10	Assigned
4u01C01	24 Aug, 2015	2.40.10.120	Assigned
4u01C02	24 Aug, 2015	2.40.10.10	Assigned
4u01D01	24 Aug, 2015	2.40.10.120	Assigned
4u01D02	24 Aug, 2015	2.40.10.10	Assigned
4u01E01	24 Aug, 2015	2.40.10.120	Assigned
4u01E02	24 Aug, 2015	2.40.10.10	Assigned
4u01F01	24 Aug, 2015	2.40.10.120	Assigned
4u01F02	24 Aug, 2015	2.40.10.10	Assigned
4u01G01	24 Aug, 2015	2.40.10.120	Assigned
4u01G02	24 Aug, 2015	2.40.10.10	Assigned
4u01H01	19 Aug, 2015	2.40.10.120	Assigned
4u01H02	19 Aug, 2015	2.40.10.10	Assigned
4u01J01	24 Aug, 2015	2.40.10.120	Assigned
4u01J02	24 Aug, 2015	2.40.10.10	Assigned

UniProtKB Entries (9)

Accession	Gene ID	Taxon	Description
Q9WMX2	POLG_HCVCO	Hepatitis C virus (isolate Con1)	Genome polyprotein
Q9WMX2	POLG_HCVCO	Hepatitis C virus (isolate Con1)	Genome polyprotein
Q9WMX2	POLG_HCVCO	Hepatitis C virus (isolate Con1)	Genome polyprotein
Q9WMX2	POLG_HCVCO	Hepatitis C virus (isolate Con1)	Genome polyprotein
Q9WMX2	POLG_HCVCO	Hepatitis C virus (isolate Con1)	Genome polyprotein
Q9WMX2	POLG_HCVCO	Hepatitis C virus (isolate Con1)	Genome polyprotein
Q9WMX2	POLG_HCVCO	Hepatitis C virus (isolate Con1)	Genome polyprotein
Q9WMX2	POLG_HCVCO	Hepatitis C virus (isolate Con1)	Genome polyprotein
Q9WMX2	POLG_HCVCO	Hepatitis C virus (isolate Con1)	Genome polyprotein